Prefatory Bioinformatics and Drug Designing

Prefatory Bioinformatics and Drug Designing Book explains basic concepts on Bioinformatics, Structural Biochemistry, Protein Biochemistry, Drug Designing and Genomics in a very lucid style. The book discusses basic and applied concepts about Bioinformatics, Databases, Search Algorithms, Alignment types and Scoring Matrices. Further, the Book sheds light on RNA Structure Determining Methods, Protein organization, folding and different Methods of Protein Secondary and Tertiary Structure Determing Methods (NMR, SC-XRD, Cryo-electron Microscopy, Homology Modelling, Threading and Ab Initio Methods). Moreover, this book then elaborates Cheminformatics and its underlying topics. Most importantly this book extensively discusses Drug Designing and Discovery where author have explained every topic including Docking its associated (Sampling and Scoring) Algorithms, Binding Energy Estimation methods, topics from Target Identification to Phase IV studies. Molecular dynamics, Protein Data Bank, Molecular Visualization Tools, Prokaryotic and Eukaryotic gene finding methods have also made part of this book. Following these topics PCR and its three main variants along with Primer Designing and confirmation have also been included. The last chapter has been added on Genomics where strong emphasis has been given to Structural and Functional Genomics topics. Clone-contig and Whole Shotgun Sequencing methods have been explained along with various types of DNA polymorphisms, DNA-Protein interaction studying methods, Protein-Protein Interaction Methods and Gene expression Studying Techniques (mRNA level).